Optimized version of Taq DNA Polymerase specially designed for DNA sequencing and SNP genotyping.
Klen SNPase DNA Polymerase is a version of Taq DNA polymerase with a special point mutation in the active site of the enzyme. The mutation leads to a higher specificity and precision of incorporating deoxy- and dideoxynucleotides.
Klen SNPase is ideal for SNP genotyping by allele-specific PCR (AS-PCR), allele-specific primer extension (AS-PEX) and mini-sequencing procedures. It is also recommended for cycle sequencing with dideoxynucleotides in automated fluorescent DNA sequencing as well as for manual DNA sequencing.
Klen SNPase enzyme has only 5'-3' polymerase activity, but the relative mutation rate is 10-15 fold lower compared to Taq DNA polymerase.
For HotStart applications, see SNPase HotStart.
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