Cat# | 152163 |
Applications | IHC, WB |
Antigen/Gene or Protein Targets | Cytochrome P450 1A2 (CYP1A2) |
Reactivity | Human |
Relevance | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. |
Host | Mouse |
Immunogen | Rat cytochrome P450 proteins |
Positive Control |
IHC: formalin-fixed, paraffin-embedded normal liver sections Western blot: recombinant P450 |
Subclass | IgG1 kappa |
Myeloma Used | P3X63Ag8.653 |
Strain | Balb/c |
Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
References | Profiling the expression of cytochrome P450 in breast cancer. Europe PMC ID: 20716162 |
For Research Use Only.
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