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{{/_source.additionalInfo}}Anti-Cytochrome P450 1B1 [5E2]
(Cat#: 152699)
Description
| Cat# | 152699 |
| Applications | ELISA, IHC, WB |
| Antigen/Gene or Protein Targets | Cytochrome P450, Family 1, Subfamily B, Polypeptide 1, CYP1B1 |
| Reactivity | Human, Mouse and Rat |
| Relevance | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development. CYP1B1 is upregulated in tumor cells and is a therapeutic target |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide - PENFDPARFLDKDGL |
| Positive Control | IHC: formalin-fixed, paraffin-embedded ovarian cancer sections; Western Blot: Recombinant human CYP1B1 expressed in lymphoblast microsomes |
| Subclass | IgG1 kappa |
| Molecular Weight (kDa) | 52 |
| Strain | Balb/c |
| Notes | Does not react with CYP1A1. ELISA pair with anti-CYP1B1, clone 5E2. By IHC this antibody detected CYP1B1 in biopsy samples of cancers of the bladder, brain, breast, colon, connective tissue, esophagus, kidney, lung, lymph node, ovary, skin, stomach, testis and uterus, but not in normal cells. |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism |
| References | Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. Europe PMC ID: 10544218 |
Image: Western blot on recombinant protein using anti-Cytochrome P450 1B1 [5E2]. Dilution refers to tissue culture supernatant.
For Research Use Only.
Boca Scientific is your premiere source for high-quality, innovative solutions for Cell Biology, Molecular Biology, Immunology, genetics and other lab products and reagents. We bring leading-edge products from our own-line and around the world to laboratories in the US and Canada. Our goal is to offer excellent solutions to drive research and discoveries backed by superior customer support.
