The ELISA-VIDITEST anti-VCA EBV IgA kit is intended for in vitro diagnostic procedures in EBV (Epstein-Barr virus)-induced and EBV-associated diseases, such as infectious mononucleosis and the chronic active EBV infection. The test can be used in the diagnosis of Burkitt’s lymphoma, nasopharyngeal carcinoma, carcinoma of the Waldeyer’s ring and in characterization of opportunistic lymphomas (oligo- and polyclonal). This kit can also be used in characterization of chronic fatigue syndrome, neuroinfection, and immunosuppression that is frequently associated with EBV-reactivation.
This assay is a solid-phase immune-analytical test. The polystyrene strips are coated with specific antigens that bear immunodominant epitopes of VCA (viral capsid antigen) complex. The anti-VCA EBV antibodies, if present in the tested sera, bind to the immobilized antigens. The antibodies in complexes with antigens are later recognized by animal anti-human IgA antibodies labeled with horseradish peroxidase. The labeled antibodies are revealed by an enzymatic reaction with a chromogenic substrate.