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Human Antibodies

153656 - Anti-Cytochrome P450 1B1 [5D3]

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Cat# 153656
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets Human cytochrome P450 1B1
Synonyms Aryl hydrocarbon hydroxylase antibody, CP1B antibody, CP1B1_HUMAN antibody, Cyp1b1 antibody, CYPIB1 antibody, Cytochrome P450 1B1 antibody, Cytochrome P450 family 1 subfamily B polypeptide 1 antibody, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody, Flavoprotein linked monooxygenase antibody, GLC3A antibody, Microsomal monooxygenase antibody, P4501B1 antibody, Xenobiotic monooxygenase antibody
Reactivity Human
Relevance Cytochrome P450 (CYP) 1B1 is overexpressed in tumor cells and is recognised as a biomarker of the tumor phenotype. Recent studies have highlighted the potential of this enzyme as a novel cancer therapeutic target, resulting in several clinical development programs focused on CYP1B1-activated prodrugs and CYP1B1 inhibitors.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; PENFDPARFLDKDGL (aa. 437-451). Peptide immunogen is identical in mouse (Mus musculus), rat (Rattus norvegicus), dog (Canis familiaris), pig (Sus scrofa) and horse (Equus caballus).
Positive Control IHC: formalin-fixed, paraffin-embedded ovarian cancer sections; Western Blot: rhCYP1B1 from lymphoblastoid cells (Gentest); 10mcg microsomal protein / lane
Subclass IgG1 kappa
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Not reactive with CYP1A1. IHC antigen retrieval: microwave 20 min @ 800W in 10mM citrate buffer, pH 6.0.
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism, Neurobiology
References Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue. Europe PMC ID: 14751521

The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Europe PMC ID: 12869499

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Europe PMC ID: 11461084

Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1. Europe PMC ID: 11264459

Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. Europe PMC ID: 10544218

 

Image: Immunohistochemistry images showing staining of formalin-fixed, paraffin-embedded human tissue sections using Anti-Cytochrome P450 1B1 [5D3]

 

For Research Use Only.