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{{/_source.additionalInfo}}Anti-Cytochrome P450 1B1 [5D3]
(Cat#: 153656)
Description
| Cat# | 153656 |
| Applications | ELISA, IHC, WB |
| Antigen/Gene or Protein Targets | Human cytochrome P450 1B1 |
| Synonyms | Aryl hydrocarbon hydroxylase antibody, CP1B antibody, CP1B1_HUMAN antibody, Cyp1b1 antibody, CYPIB1 antibody, Cytochrome P450 1B1 antibody, Cytochrome P450 family 1 subfamily B polypeptide 1 antibody, Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody, Flavoprotein linked monooxygenase antibody, GLC3A antibody, Microsomal monooxygenase antibody, P4501B1 antibody, Xenobiotic monooxygenase antibody |
| Reactivity | Human |
| Relevance | Cytochrome P450 (CYP) 1B1 is overexpressed in tumor cells and is recognised as a biomarker of the tumor phenotype. Recent studies have highlighted the potential of this enzyme as a novel cancer therapeutic target, resulting in several clinical development programs focused on CYP1B1-activated prodrugs and CYP1B1 inhibitors. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide; PENFDPARFLDKDGL (aa. 437-451). Peptide immunogen is identical in mouse (Mus musculus), rat (Rattus norvegicus), dog (Canis familiaris), pig (Sus scrofa) and horse (Equus caballus). |
| Positive Control |
IHC: formalin-fixed, paraffin-embedded ovarian cancer sections Western Blot: rhCYP1B1 from lymphoblastoid cells (Gentest); 10mcg microsomal protein / lane |
| Subclass | IgG1 kappa |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | Not reactive with CYP1A1. IHC antigen retrieval: microwave 20 min @ 800W in 10mM citrate buffer, pH 6.0. |
| Research Area | Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism, Neurobiology |
|
References |
Target validation of cytochrome P450 CYP1B1 in prostate carcinoma with protein expression in associated hyperplastic and premalignant tissue. Europe PMC ID: 14751521 The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Europe PMC ID: 12869499 Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. Europe PMC ID: 11461084 Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1. Europe PMC ID: 11264459 Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. Europe PMC ID: 10544218 |
Image: Immunohistochemistry images showing staining of formalin-fixed, paraffin-embedded human tissue sections using Anti-Cytochrome P450 1B1 [5D3].
For Research Use Only.
