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Human Antibodies

152114 - Anti-Cytochrome P450 26A1 [F27P6A1]

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Cat# 152114
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets CYP26A1 Cytochrome P450 26A1 (Retinoic acid-metabolizing cytochrome) (P450 retinoicacid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase).
Reactivity Human
Relevance Mutations in CYP26A1 are associated with caudal agenesis and spina bifida. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryo.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide PARFTHFHGE (C-terminal sequence)
Positive Control IHC: formalin-fixed, paraffin-embedded liposarcoma sections. WB: over expression lysates
Subclass IgG2b kappa
Molecular Weight (kDa) 18.4
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM plus 60 ml Fetal Bovine Serum plus 3ml L-Glutamine).
Strain Balb/c
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism
References Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis. Europe PMC ID: 26374207

The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer. Europe PMC ID: 24608339

Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers. Europe PMC ID: 16243809

Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis. Europe PMC ID: 15897573

 

Image: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections. Images are showing strong cytoplamic positivity of CYP26A1 in primary colorectal cancer using the Anti-CYP26A1 [F27P6A1]. Antigen retrieval step was required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).

 

For Research Use Only