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Human Antibodies

151865 - Anti-Cytochrome P450 4F11 [F21 P6 F5]

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Cat# 151865
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets CYP4F11- Cytochrome P450 4F11 (EC 1.14.14.1) (CYPIVF11)
Reactivity Human
Relevance Cytochrome P450 4F11 (CYP4F11) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4F11 has catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs, including benzphetamine, ethylmorphine, chlorpromazine, imipramine and erythromycin. CYP4F11 is expressed in the liver, kidney, heart, brain, and skeletal muscle and is overexpressed in ovarian and colon cancers.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide RVEPLGANSQ (C-terminal sequence)
Positive Control IHC: formalin-fixed, paraffin-embedded liposarcoma sections. western blot: kidney cell lysates
Subclass IgG1 kappa
Strain Balb/c
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism
References The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance. Europe PMC ID: 28557975

Alnabulsi et al. 2016. Characterisation of Arachidonic Acid Metabolising Enzymes in Colorectal Cancer. J Pathol. 240 Suppl 1:S1-S48. PMID: 27747872

Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers. Europe PMC ID: 16243809

Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis. Europe PMC ID: 15897573

 

 

Image: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded normal and primary colorectal tumor tissue sections using neat culture supernatants of anti-CYP4F11 [F21 P6 F5]. The photomicrographs show much stronger immunostaining of in primary colorectal tumor compared to normal colon mucosa. Cytoplasmic localisation of CYP4F11 is also observed.  

 

For Research Use Only