Cat# | 152800 |
Applications | ELISA, IHC, WB |
Antigen/Gene or Protein Targets | F Glycine Cleavage System Protein P (GCSP) |
Synonyms | GCE, GCSP, GCSP_HUMAN, GLDC, Glycine cleavage system P protein, glycine cleavage system protein P, Glycine decarboxylase, glycine decarboxylase P protein, Glycine dehydrogenase (decarboxylating) mitochondrial, Glycine dehydrogenase [decarboxylating], mitochondrial, Gycine dehydrogenase (decarboxylating), HYGN1, MGC138198, MGC138200, NKH |
Reactivity | Human |
Relevance | The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. |
Host | Mouse |
Immunogen | Ovalbumin-conjugated synthetic peptide PFSEQKRAS |
Positive Control | Western Blotting: Jurkat cell lysate |
Subclass | Not Known |
Molecular Weight (kDa) | 110 |
Myeloma Used | P3X63Ag8.653 |
Strain | Balb/c |
Notes |
Note that the peptide immunogen is identical in mouse (Mus musculus), rat (Rattus norvegicus), sheep (Ovis aries), bovine (Bos taurus), dog (Canis familiaris), horse (Equus caballus) and chicken (Gallus gallus). For IHC, use antigen retrieval - microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0 |
Research Area | Cancer, Cell Signaling & Signal Transduction, Metabolism |
Image: Immunohistochemistry of formalin-fixed, paraffin-embedded human colorectal cancer tissue using anti-GCSP [Z44P4C6*F5] showing strong cytoplasmic staining.
For Research Use Only.