Anti-MMP1 [3B6]

(Cat#: 151618)
Description
Cat# 151618
Applications IHC, IF, IP, WB
Antigen/Gene or Protein Targets Human matrix metalloproteinase 1 (MMP-1)
Reactivity Human
Relevance MMP1 cleaves collagens of types I, II, and III at one site in the helical domain. MMP1 also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; CSSFGFPRTVKH
Positive Control

IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma

Western blot: rhMMP-1, 400 ng per lane

Subclass IgG1
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes (i) no cross-reactivity in immunoblot panel (MMP-2, -3, -9); (ii) staining in antigen-positive wax-imbedded tissues
Research Area Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signaling
References

The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. Europe PMC ID: 19635101

Profiling markers of prognosis in colorectal cancer. Europe PMC ID: 16489072

Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. Europe PMC ID: 15623598

Matrix metalloproteinases and their inhibitors in gastric cancer. Europe PMC ID: 9824606

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. Europe PMC ID: 9771478

Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Europe PMC ID: 8597958

For Research Use Only 

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