Cat# | 151618 |
Applications | IHC, IF, IP, WB |
Antigen/Gene or Protein Targets | Human matrix metalloproteinase 1 (MMP-1) |
Reactivity | Human |
Relevance | MMP1 cleaves collagens of types I, II, and III at one site in the helical domain. MMP1 also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. |
Host | Mouse |
Immunogen | Ovalbumin-conjugated synthetic peptide; CSSFGFPRTVKH |
Positive Control |
IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma Western blot: rhMMP-1, 400 ng per lane |
Subclass | IgG1 |
Myeloma Used | P3X63Ag8.653 |
Strain | Balb/c |
Notes | (i) no cross-reactivity in immunoblot panel (MMP-2, -3, -9); (ii) staining in antigen-positive wax-imbedded tissues |
Research Area | Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signaling |
References |
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. Europe PMC ID: 19635101 Profiling markers of prognosis in colorectal cancer. Europe PMC ID: 16489072 Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. Europe PMC ID: 15623598 Matrix metalloproteinases and their inhibitors in gastric cancer. Europe PMC ID: 9824606 Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. Europe PMC ID: 9771478 Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Europe PMC ID: 8597958 |
For Research Use Only