Anti-MMP3 [1B4]

(Cat#: 151620)
Description
Cat# 151620
Applications ELISA, IHC, IF, IP, WB
Antigen/Gene or Protein Targets Human matrix metalloproteinase 3 (MMP-3)
Reactivity Human
Relevance Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH
Positive Control

IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophages

Western blot: rhMMP-3, 400 ng per lane

Subclass IgG1
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes Western blot: not reactive with MMP-1, MMP-2, MMP-9
Research Area Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling
References

The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. Europe PMC ID: 19635101

Profiling markers of prognosis in colorectal cancer. Europe PMC ID: 16489072

Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. Europe PMC ID: 15623598

Matrix metalloproteinases and their inhibitors in gastric cancer. Europe PMC ID: 9824606

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. Europe PMC ID: 9771478

For Research Use Only.

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