Home New Customer? Create Account
Member Login:

Home Cage Analyzer (ActualHCA)

ActualHCA - ActualHCA (Home Cage Analyzer)

PRICE


Call for Price

24/7 Data Capture and Analysis of Complex Behaviors of Group Housed Rodents in their Real Home Cage!

Rodent behavior analysis plays a vital role in drug discovery, from the development of disease models to safety pharmacology, but the activities of rodents in their homecage are almost entirely unobserved by researchers. Scientists are missing powerful digital biomarkers that can transform research. The Actual Analytics Home Cage Analyzer (ActualHCA) offers a universal solution that provides automatic, round-the-clock monitoring of socially grouped animals.

What Is the Home Cage Analyzer? 
ActualHCA is an innovative home cage analysis system that provides 24/7 monitoring of rodent behaviors in a group-housed environment that is beneficial from both data and welfare perspectives. 

ActualHCA provides automated analysis of discrete behaviors, body temperature, and locomotor activity, tagged to each individual animal within their normal social group. Isolation of individual animals is no longer needed to collect rich behavioral data. Monitoring rodents in this non-invasive manner produces highly reproducible and robust data for a wide range of scientific applications.

The HCA technology is a modular, scalable, and universal solution which can be installed in all animal facilities. As an add-on to existing rodent home cage systems, the Home Cage Analyzer is compatible with a range of rat and mouse homecages and racking systems, including IVC systems. The Home Cage Analyzer sits alongside a normal homecage and collects data from the group of animals in the adjacent cage.

HCA Units are easily installed with existing cage systems, such as this IVC rack.

 

Features

Socially Grouped Animals
RFID microchips allow the system to record and analyze individual rodent behavior whilst retaining their social groups. This provides you with analysis of discrete behaviors, temperature and locomotor activity tagged to each individual animal within their social group. In fact the social interactions within the groups are measured, these are powerful digital biomarkers that would otherwise be lost.

24/7 Analysis
Data is recorded around the clock with no time limits. Infrared lighting provides HD quality video day and night.

Universal
The System does not use a bespoke cage/arena; it really is their home cage. The HCA system is available in desktop or rack-mounted where it fits into most standard IVC racks regardless of the type of caging you currently have. There is no need to modify existing caging.

Scalable
The system is highly deployable and scalable. Multiple units can be installed per rack to meet the specifications of your experiments.

Multiple Data Levels
The system collects data for each individual animal on various levels, locomotor, temperature and behavioral. This includes discrete behaviors such as drinking, eating, and climbing, as well as circadian rhythm and locomotor data.

3RS Benefits
The quantity of longitudinal data gathered provides additional statistical power, meaning fewer animals are required. The behavioral data collected is entirely non-invasive and based on identifying individual behavior in the home cage and does not require social isolation of the animals. Remote observation capabilities facilitate enhanced welfare monitoring. Live data analytics can flag potential welfare issues in real time. 

Live Alert System
Data analysis occurs during the study. Data events from live analysis can be used to drive welfare alerts. Alerts indicate if an animal starts behavior abnormally, and perhaps needs attention from staff.

Remote Access
The system allows you to remotely observe your animals throughout the experiment via a live video feed. Not only does this save you time and resources, but it also enhances your welfare monitoring. The HD IR video allows you to zoom into specific behaviors, with live analytics flagging potential welfare issues in real time.

Multiple Applications
Testing within the home cage is suitable for a number of interest areas, including but not limited to:

  • Detecting and assessing safety/toxicological effects of candidate drugs.
  • Behavioral phenotyping of genetically altered animals.
  • Longitudinal analysis of animal cohorts across many months.
  • Drug efficacy studies.
  • Studies of circadian rhythms.
  • Studies of social interactions.

Products

The ActualHCA product line includes a Mouse Desktop, Rat Desktop, Mouse Rack, and Rat Rack. The units feature highly deployable benchtop designs. An integrated acrylic lighting backdrop ensures video consistency.

ActualHCA Mouse Desktop

ActualHCA Rat Desktop

ActualHCA Mouse Rack Installed

ActualHCA Rat Rack Installed

ActualHCA is the next generation of rodent analysis technology, surpassing all other technologies and methods available today. For more information, please contact us.

 

Publications

Bains RS, Cater HL, Stewart M, Scudamore CL, Wells SE. The effects of microchipping C57BL/6N mice on standard phenotyping tests. F1000Res. 2020;9:20. Published 2020 Jan 14. doi:10.12688/f1000research.21633.2

Banks GT, Guillaumin MCC, Heise I, et al. Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits. Sci Adv. 2020;6(33):eabb3567. Published 2020 Aug 12. doi:10.1126/sciadv.abb3567

Caldwell LJ, Davies NO, Cavone L, et al. Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations. J Neurosci. 2019;39(24):4694-4713. doi:10.1523/JNEUROSCI.2706-18.2019

Hobson L, Bains RS, Greenaway S, Wells S, Nolan PM. Phenotyping in Mice Using Continuous Home Cage Monitoring and Ultrasonic Vocalization Recordings. Curr Protoc Mouse Biol. 2020;10(3):e80. doi:10.1002/cpmo.80

Mitchell E, Thomson D, Openshaw R et al. Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions. Sci Rep. 2020;10(1). doi:10.1038/s41598-020-69130-8

Mitchell EJ, Brett RR, Armstrong JD, Sillito RR, Pratt JA. Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system - implications for the 3Rs and preclinical drug discovery. J Psychopharmacol. 2020;34(7):709-715. doi:10.1177/0269881120920455

Prior KF, van der Veen DR, O'Donnell AJ, et al. Timing of host feeding drives rhythms in parasite replication. PLoS Pathog. 2018;14(2):e1006900. Published 2018 Feb 26. doi:10.1371/journal.ppat.1006900

Stewart M, Lau P, Banks G, et al. Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities. Dis Model Mech. 2019;12(2):dmm036806. Published 2019 Feb 22. doi:10.1242/dmm.036806

Tse K, Keerie A, Sillito R et al. Rodent Big Brother: A Comparison to the Modified Irwin Test for Assessing Drug-Induced Changes in Activity and Temperature in Rats. J Pharmacol Toxicol Methods. 2017;88:195. Poster

Tse K, Sillito R, Keerie A et al. Pharmacological validation of individual animal locomotion, temperature and behavioural analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test. J Pharmacol Toxicol Methods. 2018;94:1-13. doi:10.1016/j.vascn.2018.03.008

Yip PK, Chapman GE, Sillito RR, et al. Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system. J Neurosci Methods. 2019;321:49-63. doi:10.1016/j.jneumeth.2019.04.005