News

Exciting new research continues to highlight the significance of BRCA1 promoter methylation in cancer research. A growing body of research has linked BRCA1 methylation with triple-negative breast cancer (TNBC) and high-grade serous ovarian cancer (HGSOC), with recent studies using the MethylDetect EpiMelt BRCA1 Assay to detect even low-variant-epiallele-fraction (VEF) BRCA1 epimutations. The connection between BRCA1 methylation, TNBC, and homologous recombination deficiency (HRD) further emphasizes the importance of sensitive, reliable methylation analysis. 

MethylDetect EpiMelt Assays provide fast, highly sensitive detection of locus-specific methylation using MS-HRM while minimizing PCR bias. With assay-specific methylated and non-methylated controls, EpiMelt Assays support accurate, reproducible methylation analysis across cancer, cell cycle, inflammatory response, tumor suppressor genes, and more. Assays and controls are available for more than 800 genes, providing a versatile solution for DNA methylation research.

View the publications below:

• Schwartz, M., Ibadioune, S., Delhomelle, H., et al. (2025). High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative breast cancer. Clinical Epigenetics, 17, 91.
• Pasanisi, J., Lamy, C., Lecompte, L., et al. (2026). Constitutional BRCA1 methylation is associated with high level of tumoral BRCA1 methylation and homologous recombination deficiency in triple-negative breast cancer. npj Breast Cancer.
• Lønning, P. E., Nikolaienko, O., Pan, K., et al. (2022). Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer. JAMA Oncology, 8(11), 1579–1587. Note: This study discusses the importance of studying BRCA1 promoter methylation in breast cancer research but did not use the MethylDetect Kit.

We also offer our EpiMelt’s Bisulfite Modification Standard Kit and Real-Time PCR Mastermix to complete your workflow!

Learn more about our MethylDetect DNA Methylation Kits. Request a quote. 

Achieve automatic detection of user-defined behavioral and temperature events in near real-time with the NEW ActualHCA Event Monitoring Tool. This tool allows researchers to quickly identify, review, and investigate the observations that matter the most!

Users can define custom event criteria and allow the system to automatically detect and flag relevant moments. Detected events are presented through an intuitive interface, allowing users to monitor event status, review recent event activity, and jump directly to the corresponding period in the video recording.

By automatically highlighting significant events, the ActualHCA simplifies the process of understanding what occurred, when it happened, and which animal was involved, reducing  time spent reviewing recordings and allowing reserachers to focus where it matters most!

ActualHCA is an innovative home cage analysis system that provides 24/7 monitoring of rodent behaviors in their social groups in their real home cage, with retained identity.  This is achieved through a combination of video recording, RFID technology, and analysis.  The technology utilized in Home Cage Analyzer provides automated analysis of discrete behaviors, body temperature, and locomotor activity all tagged to individual rodents within their normal social group.  This eliminates the need to isolate individual animals and introduce them into different environments, thereby impacting results. HCA is useful in detecting and assessing safety/toxicology effects of candidate drugs as well as drug efficacy studies.

Learn more about ActualHCA here. Request a quote.

View our extensive range of ActualHCA citations. 

Whats New:

Our new CRISPR & Gene Expression range from Cellecta delivers innovative tools and workflows for gene editing, helping you achieve efficient and reliable results across a wide range of applications. These solutions include pooled lentiviral CRISPR libraries, gene activation and repression systems, screening tools, and supporting reagents that enable researchers to perform both large-scale and targeted studies of gene function.

From genome-wide functional screening to targeted gene activation, repression, and knockout, CRISPR-based approaches empower researchers to uncover gene function, identify therapeutic targets, investigate disease mechanisms, and advance drug discovery.

Learn more about Cellecta. Request a quote today.

We are thrilled to announce the addition of ADS Biotec to our portfolio! ADS Biotec provides a range of products designed to enhance productivity in Cytogenetics, Molecular Genetics, and Pathology. 

ADS Biotec produces nucleic acid HPLC columns that provide superior RNA and DNA separations and purifications. The columns are comprised of uniform alkylated nonporous or macro-porous polystyrene-divinylbenzene (PS-DVB) copolymer microspheres. They are versatile and able to provide superior resolution, excellent sensitivity, and consistent performance. The columns can be used with most HPLC systems.

ADS Biotec also offers five types of optimized organoid media for three different tissue types. The HANABI Avatar™ Organoid Growth Media is enhanced for the establishment and propagation of human and murine colon, liver, and oviduct tissues. Each kit comes with a 100mL bottle of Base Media and a 4mL vial of media supplement, making it all inclusive and easy to use. View the brochure here. 

Learn more here. View our Organoid Growth Media whitepaper.

Questions? Contact us or visit our ADS Biotec FAQ!

We are thrilled to announce the launch of ReadyTector® Pure! 

ReadyTector® Pure is a One-Step-Detection-Solution for Immunoblots enabling immunodetection. It features a speedy, efficient, and effective protocol, allowing you to perform blocking, primary antibody binding, and secondary antibody binding simultaneously, greatly simplifying and accelerating the workflow. ReadyTector® Pure is compatible with multiple detection labels, including horseradish peroxidase (HRP), alkaline phosphatase (AP), fluorescent dyes, and nanoparticles as well as multiplexing approaches. Optimal primary and secondary antibody concentrations must be empirically determined.

Additional bottles of 10x wash buffer can be purchased separately.

Learn more here. See ReadyTector® All-in-One Solution for Western Blotting.

We are pleased to announce that Boca Scientific Inc. will be attending Immunology 2026 and would like to invite you to stop by our booth #639!

Here you can learn about our Immunoassay Optimization Reagents, Cell Culture Media, DNA Polymerases, DNA and RNA Collection and Extraction options, Methylation Detection Assays, Transfection Reagents, Agrisera Anitbodies, Gelatex HaloSpun Scaffolds, Inserts, and Cell Crowns, and Much More.

If you would like to set up a time to meet with us at Immunology 2026, please contact us! Alternatively, please feel free to stop by our booth anytime during exhibit hall hours.

We look forward to meeting you and discussing our wide range of innovative immunology products!

We are excited to announce the launch of e-Myco™ VALiD-Q Real-time PCR Kit (v3.0 PRO). This kit provides a fast, reliable, and guideline-compliant method to detect mycoplasma contamination in cell-based manufacturing processes. The assay offers comprehensive coverage of international pharmacopeia standards (EP, USP, JP, and Korea MFDS), enabling simultaneous detection of compendial reference species within a single integrated panel. 

Achieve rapid PCR detection of Mycoplasma and related Mollicutes class in just 53 minutes!

Learn more here. See our full line of Mycoplasma Detection Kits here and our full line of Cell Culture products here. 

Request a quote today.

Agrisera provides off-the-shelf antibodies for plant and algal research, with reactivity to thousands of species! 

January through June 2026, receive 20% off our line of Secondary Antibodies with code SEC20! The secondary antibodies come conjugated to a variety of enzymes and dyes including biotin, horseradish peroxidase, and alkaline phosphatase.

The full Agrisera product line offerings include Plant & Algal, Human & Animal, Secondary, TAG, and Bacterial & Fungal antibodies.

Learn more about Agrisera Antibodies. Request a quote today.

We are thrilled to share a landmark, multi-company validation showing home-cage monitoring detects CNS safety signals missed by traditional Irwin/FOB testing. Home Cage Analyzer offers welfare benefits, and increased sensitivity for 24/7 data capture!

This collaborative validation demonstrates that HCA can uncover clinically relevant behavioral effects that traditional episodic assessments simply don’t capture. 24x7 automated home-cage monitoring (HCA) delivers earlier warning of CNS effects, improves animal welfare, and reduces costs across the drug discovery pipeline.

The work involved scientists from Actual Analytics, the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), AstraZeneca, GSK, Janssen Pharmaceuticals, Charles River Laboratories, ICON plc, and The University of Edinburgh. Learn more about ActualHCA: /products/home-cage-analyzer

Read the published paper: https://lnkd.in/euV-GpZZ

View the press release: /images/pdf/Actual_Analytics-Press_release.pdf

Join us in San Diego, CA November 16-19th for Neuroscience 2025! 

Visit Booth 2415 to learn about our Home Cage Analyzer System (HCA), Immunoassay Optimization Reagents, DNA Polymerases & Master Mixes, Cell Culture Media, BOCARACK Freezer/Refrigerator Storage Systems, DNA/RNA Sampling, Stabilization, and Isolation, Methylation Detection Assays, Lab Columns, Transfection Reagents, Magnetic Silica Beads, Agrisera Antibodies, and Much More!

We look forward to meeting you and discussing your fascinating research!

For more information, please contact us.

Enjoy the last month of summer with our exciting new promotion! For each unit purchased of our Xpert cDNA Synthesis Supermix, receive 1ml of Xpert Fast SYBR Blue FREE. 

Xpert cDNA Synthesis Supermix provides fast and efficient synthesis of high-quality, full-length (up to 8-10kb) first strand cDNA with excellent yields from purified poly(A)+ mRNA or total RNA templates. This optimized master mix has integrated gDNA eraser for elimination of residual DNA.

Xpert Fast SYBR Blue offers high sensitivity and specificity qPCR with SYBR. This mastemix contains all necessary components for the amplification and detection of DNA in qPCR, except the primers and template. It includes an inert blue dye for visualization during pipetting!

Offer valid until 9/15/25.

Learn more on our website. Request a quote today.

We are excited to announce we will be attending analytica USA 2025 in Columbus, Ohio! Join us September 10th-12th to learn more about Boca Scientific and our wide range of cutting edge research solutions.

Visit booth 138 to learn about our Immunoassay Optimization Reagents, BOCARACK Freezer/Refrigerator Storage Systems, Cell Culture Media, DNA Polymerases, DNA and RNA Collection and Extraction options, Methylation Detection Assays, Agrisera Antibodies, Home Cage Analyzer System (HCA), and Much More!

We look forward to meeting you and discussing our wide range of products!

For more information, please contact us.