ActualHCA Citations

Home Cage Analyzer

• Building a robust CNS screening strategy: Integrating in vivo and in vitro assays to better predict CNS risk.

  Connor et al., (2025)

• The Results of a Multi Company Validation of the ActualHCA™ Home Cage Monitoring System for Rodent CNS Safety Pharmacology Studies.

  Cherian et al., (2023)

• FUS-NLS mutation causes neurodevelopmental and systemic metabolic alterations.

  Ali et al., Dis Model Mech.  (2023)

• Induction of choroidal neovascularization by laser treatment in mice affects home cage behavior.

  Woo Park et al., Invest. Ophthalmol. Vis. Sci. (2023)

• Longitudinal home-cage automated assessment of climbing behavior shows sexual dimorphism and aging-related decrease in C57BL/6J healthy mice and allows early detection of motor impairment in the N171-82Q mouse model of Huntington’s disease.

  Bains et al., Front. Behav. Neurosci (2023)

• Comprehensive longitudinal study of home-cage activity, including climbing, reveals new complex phenotypic profile in the N171-82Q HD mouse model with implications for refined preclinical studies.

  Bains et al., bioRxiv (2023)

• Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen.

  Wotton et al., Pain (2022)

• Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain.

  Tejada et al., Biomedicines (2022)

• Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain.

  Nunez-Badinez et al., Pain (2021)

• Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.

  Wilcox et al., iScience (2021)

• Mice lacking melatonin MT2 receptors exhibit attentional deficits, anxiety and enhanced social interaction.

  Thomson et al., Journal of Psychopharmacology (2021)

• Phenotyping in Mice Using Continuous Home Cage Monitoring and Ultrasonic Vocalization Recordings.

  Hobson et al., Current Protocols in Mouse Biology (2020)

• Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits.

  Banks et al., Science Advances (2020)

• The effects of microchipping C57BL/6N mice on standard phenotyping tests.

  Bains et al., F100 Research (2020)

• Temporal dissociation of phencyclidine: Induced locomotor and social alterations in rats using an automated homecage monitoring system - implications for the 3Rs and preclinical drug discovery.

  Mitchell et al., Journal of Psychopharmacology (2020) 

• Drug-responsive autism phenotypes in the 16p11.2 deletion mouse model: a central role for gene-environment interactions.

  Mitchell et al., Nature Research: Scientific Reports (2020)

• Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.

  Stewart et al., Disease Models & Mechanisms (2019)

• Studies on long term behavioral changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system.

  Yip et al., Journal of Neuroscience Methods (2019)

• Regeneration of Dopaminergic Neurons in Adult Zebrafish Depends on Immune System Activation and Differs for Distinct Populations.

  Caldwell et al., Journal of Neuroscience (2019)

• Timing of host feeding drives rhythms in parasite replication.

  Prior et al., PLOS Pathogens (2018)

• Pharmacological validation of individual animal locomotion, temperature and behavioral analysis in group-housed rats using a novel automated home cage analysis system: A comparison with the modified Irwin test.

  Tse et al., Journal of Pharmacological and Toxicological Methods (2018)

• Rodent Big Brother: Optimal Positioning of the Subcutaneous RFID Microchip Transponder for 24/7 Home Cage Monitoring in Rats.

  Tse et al., Journal of Pharmacological and Toxicological Methods (2017)

• Rodent Big Brother: A Comparison to the Modified Irwin Test for Assessing Drug-Induced Changes in Activity and Temperature in Rats.

  Tse et al., Journal of Pharmacological and Toxicological Methods (2017)

• Rodent Big Brother: Automated Video Recognition of Home Cage Behaviours in Safety Pharmacology and Toxicology Studies in Group-Housed Rats.

  Tse et al., Journal of Pharmacological and Toxicological Methods (2017)

• Assessing Mouse Behaviour Throughout The Light/Dark Cycle Using Automated In-Cage Analysis Tools.

  Bains et al., Journal of Neuroscience Methods (2017)

• Automated Recording Of Home Cage Activity And Temperature Of Individual Rats Housed In Social Groups: The Rodent Big Brother Project.

  Redfern et al., PLOS One (2017)

• Analysis of Individual Mouse Activity in Group Housed Animals of Different Inbred Strains Using a Novel Automated Home Cage Analysis System.

  Bains et al., Frontiers Behavioural Neuroscience (2016)

• Tracking Of Individual Mice In A Social Setting Using Video Tracking Combined With Rfid Tags.

  Armstrong et al., Proceedings of Measuring Behaviour (2016)

• Circadian rhythms in malaria parasites?

  Prior et al., University of Edinburgh Poster (2015)

• Rodent Big Brother: Development And Validation Of A Home Cage Automated Behavioural Monitoring System For Use In Repeat-Dose Toxicity Studies In Rats.

  Redfern et al., Eurotox Poster (2014)