Exciting new research continues to highlight the significance of BRCA1 promoter methylation in cancer research. A growing body of research has linked BRCA1 methylation with triple-negative breast cancer (TNBC) and high-grade serous ovarian cancer (HGSOC), with recent studies using the MethylDetect EpiMelt BRCA1 Assay to detect even low-variant-epiallele-fraction (VEF) BRCA1 epimutations. The connection between BRCA1 methylation, TNBC, and homologous recombination deficiency (HRD) further emphasizes the importance of sensitive, reliable methylation analysis.
MethylDetect EpiMelt Assays provide fast, highly sensitive detection of locus-specific methylation using MS-HRM while minimizing PCR bias. With assay-specific methylated and non-methylated controls, EpiMelt Assays support accurate, reproducible methylation analysis across cancer, cell cycle, inflammatory response, tumor suppressor genes, and more. Assays and controls are available for more than 800 genes, providing a versatile solution for DNA methylation research.
View the publications below:
- Schwartz, M., Ibadioune, S., Delhomelle, H., et al. (2025). High prevalence of constitutional BRCA1 epimutation in patients with early-onset triple-negative breast cancer. Clinical Epigenetics, 17, 91.
- Pasanisi, J., Lamy, C., Lecompte, L., et al. (2026). Constitutional BRCA1 methylation is associated with high level of tumoral BRCA1 methylation and homologous recombination deficiency in triple-negative breast cancer. npj Breast Cancer.
- Lønning, P. E., Nikolaienko, O., Pan, K., et al. (2022). Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer. JAMA Oncology, 8(11), 1579–1587. Note: This study discusses the importance of studying BRCA1 promoter methylation in breast cancer research but did not use the MethylDetect Kit.
We also offer our EpiMelt’s Bisulfite Modification Standard Kit and Real-Time PCR Mastermix to complete your workflow!
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