HS-Nuclease is a recombinant form of Serratia marcescens extracellular endonuclease (encoded by the same gene as Bezonase®) produced in E. coli using a proprietary process.
This nonspecific endonuclease hydrolyzes both single- and double-stranded nucleic acids (DNA and RNA) to 5'-phosphorylated oligonucleotides of 1 - 4 bases in length. HS-Nuclease is a highly purified homodimer of 27 kDa subunits that has exceptionally high specificity and is free of protease activity.
HS-Nuclease is ideal for digesting nucleic acids and reducing viscosity during protein purification and sample preparation.