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Human Antibodies

152601 - Anti-Alanyl-tRNA Synthetase [M6-P2E5]

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Cat# 152601
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets Alanyl-tRNA Synthetase (AARS)
Reactivity Human
Relevance The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity with the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific amino acids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.
Host Mouse
Immunogen Peptide – TSFAQLRLGD (amino acid 956-965)
Positive Control Western Blot - Hela cell lysates; IHC - Human breast cancer tissue
Subclass IgG1 kappa
Molecular Weight (kDa) 110
Notes Please note for IHC antigen retrieval is required: ,icrowave 20 min @ 800W in 10 mM citrate buffer, pH 6.0
Research Area Epigenetics & Nuclear Signalling

 

Image: Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections. Strong cytoplasmic staining is observed in breast carcinoma using Anti-Alanyl-tRNA Synthetase [M6-P2E5]. Antigen retrieval step was required (microwave 10 min @ 950W in 0.01M sodium citrate. buffer, pH 6.0).

 

For Research Use Only