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Human Antibodies

151622 - Anti-a-MMP9 [4A3]

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Cat# 151622
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets Activated MMP9 (matrix metalloproteinase 9)
Reactivity Human and Rat
Relevance Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumor invasion and metastasis
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; acetylated-FQTFEGDLK
Positive Control IHC: Formaldehyde-fixed, wax-embedded oesophegal adenocarcinomaWestern Blot Activated recombinant MMP-9, 400ng per lane
Subclass IgG1 kappa
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing L-Glutamine and 20% Fetal Bovine serum (DH20) .
Strain Balb/c
Notes Western Blot: not reactive with proenzyme of MMP-9, nor proenzyme or activated forms of MMP-2
Research Area Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Protein Degradation
References Effect of the non-specific matrix metalloproteinase inhibitor Doxycycline on endometriotic implants in an experimental rat model. Europe PMC ID: 26136898


Human matrix metalloproteinase-9: activation by limited trypsin treatment and generation of monoclonal antibodies specific for the activated form. Europe PMC ID: 9851689

 

 Image: Immunohistochemical localisation of activated MMP-9 in oesophageal cancer using mAb 4A3

 

For Research Use Only