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Human Antibodies

152792 - Anti-CIDE A [V62P1E3*B10]

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Cat# 152792
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets Cell Death-Inducing DFFA-Like Effector A (CIDE A)
Synonyms Cell death activator CIDE A, Cell Death Inducing DFFA Like Effector A, cell death inducing DNA fragmentation factor, alpha subunit like effector A, CIDE-A, CIDEA
Reactivity Human
Relevance Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICARD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B (for cell death inducing DFF like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE A is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE A is expressed in many tissues.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide- QAKGRFTCG
Positive Control IHC - formalin-fixed, paraffin-embedded multi tumor tissue microarray
Subclass IgG1 kappa
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes For IHC antigen retrieval: microwave 20 min @ 800W in 10 mM citrate buffer, pH 6.0
Research Area Apoptosis and Programmed Cell Death, Cancer, Cardiovascular, Cell Cycle, Epigenetics & Nuclear Signalling, Metabolism, Protein Degradation
References The expression of brown fat-associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis. Europe PMC ID: 30737786

 

Image: IHC photomicrographs showing weak cytoplasmic staining of Anti-CIDE A [V62P1E3*B10] in normal colon mucosa. IHC was performed on formalin-fixed, paraffin-embedded normal colon mucosa.

 

For Research Use Only.