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Human Antibodies

152159 - Anti-Cytochrome P450 4V2 [M29-P3B10]

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Cat# 152159
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2)
Synonyms Cytochrome P450; Family 4; Subfamily V; Polypeptide 2; Docosahexaenoic Acid Omega-Hydroxylase CYP4V2; CYP4AH1; BCD
Reactivity Human
Relevance Cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP4V2 catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. CYP4V2 may have a role in fatty acid and steroid metabolism in the eye and its mutations are associated with Bietti's crystalline dystrophy (BCD) and retinitis pigmentosas.
Host Mouse
Immunogen Peptide sequence – KREELGLEGQ (amino acids 495 – 504)
Positive Control ELISA- Peptide immunogen; Western Blot- Human liver microsomes; IHC- Human liver
Subclass IgG1 kappa
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM + 60 ml Fetal Bovine Serum plus 3ml L-Glutamine + 3ml of Penicillin -Streptomycin.
Strain Balb/c
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism
References The differential expression of omega-3 and omega-6 fatty acid metabolising enzymes in colorectal cancer and its prognostic significance. Europe PMC ID: 28557975

 

For Research Use Only.