Cat# | 152670 |
Applications | IHC, WB |
Antigen/Gene or Protein Targets | Heterogeneous nuclear ribonucleoprotein K – isoform 1, hnRNP-K, hnRNPK |
Reactivity | Human |
Relevance | The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid-directed processes. This protein has recently emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several human cancers and its aberrant cytoplasmic localization has been associated with a worse prognosis for patients, suggesting that it has a role in cancer progression. |
Host | Mouse |
Immunogen | Ovalbumin-conjugated synthetic peptide SVKQYSGKFF (C-terminal sequence) |
Positive Control |
IHC: formalin-fixed, paraffin-embedded colorectal cancer sections Western Blotting: Jurkat cell lysate |
Subclass | IgG1 kappa |
Strain | Balb/c |
Notes | Immunogen peptide sequence is common to mouse, rat, rabbit, chicken, sheep, dog, pig, horse. |
Research Area | Cell Cycle, Epigenetics & Nuclear Signaling |
Image: Immunohistochemistry was performed using anti-hnRNP-K (isoform1) [N10 P2D3*G2] on formalin-fixed, paraffin-embedded tissue sections. Strong nuclear immunostaining was observed in normal skin (A). Nuclear and cytoplasmic immunostaining was observed in breast carcinoma (B). This is in agreement with existing literature as hnRNPK shows aberrant localisation in tumors.
For Research Use Only