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{{/_source.additionalInfo}}Anti-MMP3 [1B4]
(Cat#: 151620)
Description
| Cat# | 151620 |
| Applications | ELISA, IHC, IF, IP, WB |
| Antigen/Gene or Protein Targets | Human matrix metalloproteinase 3 (MMP-3) |
| Reactivity | Human |
| Relevance | Human matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinases (MMP) family that are peptidases involved in the breakdown of extracellular matrix proteins. MMP-3 degrades fibronectin, laminin, gelatins of type I, III, IV, and V; collagen of type II, III, IV, X, and IX, and proteoglycans. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling. The enzyme is also thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide; CKSLRKLEPELH |
| Positive Control |
IHC: formalin-fixed, paraffin-embedded lung containing intra-alveolar macrophages Western blot: rhMMP-3, 400 ng per lane |
| Subclass | IgG1 |
| Myeloma Used | P3X63Ag8.653 |
| Strain | Balb/c |
| Notes | Western blot: not reactive with MMP-1, MMP-2, MMP-9 |
| Research Area | Adhesion, Cancer, Cardiovascular, Epigenetics & Nuclear Signalling |
| References |
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. Europe PMC ID: 19635101 Profiling markers of prognosis in colorectal cancer. Europe PMC ID: 16489072 Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. Europe PMC ID: 15623598 Matrix metalloproteinases and their inhibitors in gastric cancer. Europe PMC ID: 9824606 Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. Europe PMC ID: 9771478 |
For Research Use Only.
Boca Scientific is your premiere source for high-quality, innovative solutions for Cell Biology, Molecular Biology, Immunology, genetics and other lab products and reagents. We bring leading-edge products from our own-line and around the world to laboratories in the US and Canada. Our goal is to offer excellent solutions to drive research and discoveries backed by superior customer support.
