|Applications||ELISA, IHC, WB|
|Antigen/Gene or Protein Targets||TIMP2 (tissue inhibitor of metalloproteinases 2)|
|Reactivity||Human, Mouse, Rat and Zebrafish|
Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumor invasion and metastasis.
Expression of TIMP2 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.
|Immunogen||Ovalbumin-conjugated synthetic peptide; DSGNDIYGNPI|
IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma
Western blot: rhTIMP-2, 400 ng per lane
|Recommended Growing Conditions||Dulbecco’s media containing L-Glutamine and 20% Fetal Bovine serum (DH20) .|
|Notes||(i) no cross-reactivity with TIMP-1 in immunoblot, (ii) staining in antigen-positive wax-embedded tissues|
|Research Area||Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Protein Degradation|
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. Europe PMC ID: 28602351
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. Europe PMC ID: 19635101
Profiling markers of prognosis in colorectal cancer. Europe PMC ID: 16489072
Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. Europe PMC ID: 15623598
Matrix metalloproteinases and their inhibitors in gastric cancer. Europe PMC ID: 9824606
Image: Immunohistochemistry on Zebrafish embryo.
For Research Use Only.
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