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Human Antibodies

152163 - Anti-Cytochrome P450 1A2 [3B8C1]

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Cat# 152163
Applications IHC, WB
Antigen/Gene or Protein Targets Cytochrome P450 1A2 (CYP1A2)
Reactivity Human
Relevance Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin.
Host Mouse
Immunogen Rat cytochrome P450 proteins
Positive Control IHC: formalin-fixed, paraffin-embedded normal liver sections; western blot: recombinant P450
Subclass IgG1 kappa
Myeloma Used P3X63Ag8.653
Strain Balb/c
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism
References Profiling the expression of cytochrome P450 in breast cancer. Europe PMC ID: 20716162

 

For Research Use Only