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Human Antibodies

151837 - Anti-TIMP2 [3A4]

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Cat# 151837
Applications ELISA, IHC, WB
Antigen/Gene or Protein Targets TIMP2 (tissue inhibitor of metalloproteinases 2)
Reactivity Human, Mouse, Rat and Zebrafish
Relevance Matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes as well as in disease processes. Tissue inhibitors of metalloproteinases (TIMPs) are the main physiological regulators of the MMPs. The TIMPs are secreted proteins that complex with individual MMPs and regulate the activity of specific MMPs. Together, the MMPs and TIMPs form a complex biological system strictly controlling degradation of ECM. The MMPs and TIMPs have a significant role in facilitating tumor invasion and metastasis.

Expression of TIMP2 has been identified in individual studies as prognostic biomarkers in established and locally advanced colorectal cancer.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide; DSGNDIYGNPI
Positive Control IHC: formalin-fixed, paraffin-embedded colonic adenocarcinoma Western blot: rhTIMP-2, 400 ng per lane
Subclass IgG2b
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing L-Glutamine and 20% Fetal Bovine serum (DH20) .
Strain Balb/c
Notes (i) no cross-reactivity with TIMP-1 in immunoblot, (ii) staining in antigen-positive wax-imbedded tissues
Research Area Adhesion, Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Protein Degradation
References A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. Europe PMC ID: 28602351

The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers. Europe PMC ID: 19635101

Profiling markers of prognosis in colorectal cancer. Europe PMC ID: 16489072

Matrix metalloproteinase/tissue inhibitors of matrix metalloproteinase phenotype identifies poor prognosis colorectal cancers. Europe PMC ID: 15623598

Matrix metalloproteinases and their inhibitors in gastric cancer. Europe PMC ID: 9824606

 

Image: Immunohistochemistry on Zebrafish embryo.

 

For Research Use Only.