MagSi-S SH Beads with Thiol Surface

Magnetic silica beads are surface activated magnetic particles intended for covalent immobilization of proteins (e.g. antibodies, enzymes), peptides, nucleic acids or other molecules of interest. After the molecule of interest (ligand) is coupled to the magnetic particles, the resulting beads can be used in downstream applications such as detecting, enriching, or cleaving specific target molecules. The simple and efficient collection in magnetic fields allows for easy rinsing and removal of excess reagents and ligand after coupling. 

MagSi-S SH Beads have a thiol modified surface and are intended for SH coupling chemistry. They are useful for proteins containing cysteines, but there is a risk of multiple coupling. 

These beads come in three different diameters: 600nm, 1µm and 3µm. 600nm beads have a larger surface area, and the sedimentation time of 600nm beads is approximately 4 times slower than that of 1µm beads. This allows longer incubation times without shaking/mixing. Magnetic silica beads with a diameter of 3µm have stronger magnetic properties and will separate approximately 4 times faster than 600nm beads under the same conditions.