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{{/_source.additionalInfo}}Anti-FVIIa | Coagulation factor VIIa (500 µg)
(Cat#: AS00 001-500)
Description
- Immunogen: Recombinant human Factor VIIa (NovoSeven ®, Novo Nordisk A/S Denmark)
- Host: Rabbit
- Clonality: Polyclonal
- Purity: Immunogen affinity purified IgG in PBS pH 7.4.
- Format: Lyophilized
- Quantity: 500 µg
- Reconstitution: For reconstitution add 500 µl of sterile water
- Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them, to avoid any losses that might occur from material adhering to the cap or sides of the tube.
- Tested applications: Prothrombin assay with human plasma (PT), thrombin generation assay, inhibition assay with Factor VIIa with TF and a chromogenic substrate, inDirect ELISA (I-ELISA)
- Recommended dilutions: 1 : 15 000 (I-ELISA)
- Expected | apparent MW: 52 kDa
- Confirmed reactivity: Human
- Not reactive in: No confirmed exceptions from predicted reactivity are currently known
- Factor VIIa (FVIIa) is a key serine protease involved in the initiation of the coagulation cascade. FVIIa requires tissue factor (TF), a membrane bound protein, as an essential cofactor for maximal activity towards its biological substrates Factor X, Factor IX and Factor VII (FVII).
- Lopez-Vilchez et al. (2009). Traffic of rFVIIa through Endothelial Cells and Redistribution into Subendothelium: Implications for a Prolonged Hemostatic Effect. Journal of Coagulation Disorders, October 1: (1). (immunolocalization)
- No significant difference in binding to Factor VII and Factor VIIa.Antibody is purified to total IgG fraction, followed by purification on specific FVIIa column.
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