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{{/_source.additionalInfo}}Anti-8-Hydroxyguanosine | DNA/RNA oxidative damage (clone 15A3)
(Cat#: AS10 708-25)
Description
- Immunogen: 8-hydroxy-guanosine-BSA and – casein conjugates
- Host: Mouse
- Clonality: Monoclonal
- Purity: Total IgG fraction. Protein G purified.
- Format: Liquid
- Quantity: 25 µg
- Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
- Tested applications: ELISA (ELISA), Immunoaffinity chromatography (IAP), Immunohistochemistry on frozen tissue and paraffin-embedded (IHC-Fr-P)
- Recommended dilutions: The optimal working dilution should be determined by the investigator
- Confirmed reactivity: Recognizes markers of oxidative damage to DNA (8-hydroxy-2’-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine)
- Not reactive in: No confirmed exceptions from predicted reactivity are currently known
- Oxidative derivate of guanosine is called 8-Hydroxyguanosine (8OHdG) and is used as a popular biomarker of oxidative stress.
- Poborilova et al. (2015). DNA hypomethylation concomitant with the overproduction of ROS induced by naphthoquinone juglone on tobacco BY-2 suspension cells. Environmental and Experimental Botany, Volume 113, May 2015, Pages 28–39.Haigh and Drew (2015). Cavitation during the protein misfolding cyclic amplification (PMCA) method - The trigger for de novo prion generation? Biochem Biophys Res Commun. 2015 Apr 17. pii: S0006-291X(15)00726-3. doi: 10.1016/j.bbrc.2015.04.048.
- Protocol for immunostaining using this antibody can be found here.
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