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{{/_source.additionalInfo}}Anti-NpHR | Halorhodopsin
(Cat#: AS12 1851)
Description
- Immunogen: KLH-conjugated synthetic peptide derived from Natronomonas pharaonis halorhodopsin sequences UniProt: A0A1U7EU03
- Host: Rabbit
- Clonality: Polyclonal
- Purity: Immunogen affinity purified serum in PBS pH 7.4.
- Format: Lyophilized
- Quantity: 50 µg
- Reconstitution: For reconstitution add 50 µl of sterile water
- Storage: Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
- Tested applications: Immunofluorescence (IF), Western blot (WB)
- Recommended dilutions: 1 : 200 (IF), 1 : 1000 (WB)
- Expected | apparent MW: 30.9 | 30 kDa
- Confirmed reactivity: Natronomonas pharaonis
- Not reactive in: Halobacterium salinarum (HsHR and HsBR)
- Halorhodopsin (HR) is a hyperpolarizing light-driven ion pump from the halophilic archaea bacterium Natronomonas pharaonis. HR uses the energy of yellow light (excitation maximum near 580 nm) to mediate primarily chloride but also bromide, iodide, and nitrate import into the cell against their electrochemical gradients.
- Huang et al. (2024). Suppression of presynaptic corticostriatal glutamate activity attenuates L-dopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's disease mice. Neurobiol Dis. 2024 Apr:193:106452. doi: 10.1016/j.nbd.2024.106452. Alfonsa et al. (2015) The contribution of raised intraneuronal chloride to epileptic network activity. J Neurosci. 2015 May 20;35(20):7715-26. doi: 10.1523/JNEUROSCI.4105-14.2015.
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