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{{/_source.additionalInfo}}Anti-Transthyretin 56-61, amyloid specific (mouse monoclonal)
(Cat#: AS16 3113)
Description
- Immunogen: Recombinant protein corresponding to the Human wild type Transthyretin. GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE The epitope has been mapped to residue 56-61
- Host: Mouse
- Clonality: Monoclonal
- Purity: Affinity purified in PBS pH 7.4.
- Format: Lyophilized
- Quantity: 100 µg
- Reconstitution: Add 100 µl sterile water to reconstitute to 1 mg/ml
- Storage: Store lyophilized/reconstituted at 4°C, Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
- Tested applications: ELISA (ELISA), Immunohistochemistry (IHC), Western blot (WB)
- Recommended dilutions: 1:1000 (ELISA), 1:500 (IHC), 1:1000 (WB)
- Expected | apparent MW: 155
- Confirmed reactivity: Human Transthyretin Amyloids
- Not reactive in: No confirmed exceptions from predicted reactivity are currently known
- Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 10% of the population above 80 years of age with depositions mainly found in the heart.Monoclonal IgG1 antibody. Amyloid specific for human Transthyretin. Detects the C-terminal fragment 49-127 frequently formed in vivo.
- Goldsteins et al. (1999). Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6): 3108–3113
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