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{{/_source.additionalInfo}}Anti-RuvA | Holliday junction ATP-dependent DNA helicase
(Cat#: AS21 4543)
Description
- Immunogen: Purified, full length RuvA protein of Escherichia coli, UniProt: P0A809
- Host: Rabbit
- Clonality: Polyclonal
- Purity: Serum. Contains 0.05 % sodium azide.
- Format: Liquid
- Quantity: 100 µl
- Storage: Store at 4°C for up to 6 months, for longer storage-20°C is recommended; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
- Tested applications: ELISA (ELISA), Western blot (WB)
- Expected | apparent MW: 1 : 3000 (WB)
- Confirmed reactivity: 22 kDa
- RuvA protein of Escherichia coli binds specifically to the Holliday structure which is the intermediate of recombination at the late stage of homologous recombination and recombination repair, and forms a complex with RuvB motor protein, allowing the migration of Holliday junction using ATP hydrolysis energy and expands the heteroduplex region. In solution, it forms a tetramer and binds to the cross-like DNA of the Holliday junction from below and above, holding it in between
- Shinagawa & Iwasaki (1996). Processing the holliday junction in homologous recombination. Trends Biochem Sci. 1996 Mar;21(3):107-11. PMID: 8882584.Iwasaki et al. (1992) Escherichia coli RuvA and RuvB proteins specifically interact with Holliday junctions and promote branch migration. Genes Dev. 1992 Nov;6(11):2214-20. doi: 10.1101/gad.6.11.2214. PMID: 1427081.
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