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{{/_source.additionalInfo}}Mouse Genome-Wide CRISPRa sgRNA Libraries
Mouse Genome-Wide CRISPRa sgRNA Library (plasmid), 200ug(Cat# KAMGW-109-P)
Description
This off-the-shelf, ready-to-use mouse genome-wide sgRNA library is designed to activate gene expression. The CRISPRa sgRNA Library targets over 19,000 mouse protein-coding genes, with 5 sgRNAs per gene.This is the only system that enables genome-wide gain-of-function screens to identify endogenous genes that alter phenotypes when activated rather than knocked out or turned off. Unlike a CRISPR knockout, the induction is reversible since it does not alter the underlying DNA structure. This library provides a tool for identifying candidate therapeutic targets involved in the regulation of growth, differentiation, disease pathogenesis, and other biological responses. Available formats include 200 ug plasmid and pre-packaged viral libraries at 2 x 10^8 TU and 1 x 10^9 TU.
- Designed to work with deactivated spCas9 (dCas9) complexed with an activator (dCas9-VPH) to activate gene expression
- Five CRISPRa dual-sgRNA constructs target each gene.
- Targets nearly 19,000 human coding regions
- Library includes 3,700 non-targeting sgRNA controls
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Targeted Gene Activation
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Gain of Function studies
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Functional Genetic Screening
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Identification of Novel Targets for Therapeutics
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Biomarker Analysis
|
Cat # |
Product Name |
Size |
| KAMGW-109-P | Mouse Genome-Wide CRISPRa sgRNA Library (plasmid) |
200 ug |
|
KAMGW-109-V8 |
Mouse Genome-Wide CRISPRa sgRNA Library (virus) |
2 x 10^8 TU |
|
KAMGW-109-V9 |
Mouse Genome-Wide CRISPRa sgRNA Library (virus) |
1 x 10^9 TU |
Boca Scientific is your premiere source for high-quality, innovative solutions for Cell Biology, Molecular Biology, Immunology, genetics and other lab products and reagents. We bring leading-edge products from our own-line and around the world to laboratories in the US and Canada. Our goal is to offer excellent solutions to drive research and discoveries backed by superior customer support.
