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{{/_source.additionalInfo}}Anti-ASyM | Mouse anti-human alpha synuclein N-terminal (clone number 4,2)
(Cat#: AS13 2719)
Description
- Immunogen: Synthetic peptide derived from human alpha-synuclein N-terminal Met1-Val15
- Host: Mouse
- Clonality: Monoclonal
- Purity: Immunogen affinity purified serum in PBS pH 7.4.
- Format: Lyophilized
- Quantity: 50 µg
- Reconstitution: For reconstitution add 50 µl of sterile water
- Storage: For short time storage add sodium azide and store at +4°C. For long time storage store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
- Tested applications: Dot blot (Dot), ELISA (ELISA), Immunohistochemistry (IHC)
- Recommended dilutions: 1-2 µg/ml (Dot), 2-4 µg/ml (ELISA capture), 10 µg/ml (IHC)
- Expected | apparent MW: 14 kDa
- Confirmed reactivity: Human
- Not reactive in: No confirmed exceptions from predicted reactivity are currently known
- Alpha-synuclein is normally an unstructured soluble protein that can aggregate to form insoluble fibrils in pathological conditions characterized by Lewy bodies, such as Parkinson's disease, dementia with Lewy-bodies, and multiple system atrophy.
- Tanudjojo et al. (2021) Phenotypic manifestation of α-synuclein strains derived from Parkinson's disease and multiple system atrophy in human dopaminergic neurons. Nat Commun. 2021 Jun 21;12(1):3817. doi: 10.1038/s41467-021-23682-z. PMID: 34155194; PMCID: PMC8217249.
- This antibody will recognize human SNCA monomers and multimers in Western blot. This antibody binds weakly to fibrills in IHC.Cross reactivity of this antibody to synuclein beta was not determined.This antibody can be used as a capture antibody in ELISA, combined with AS08 358 as a detection antibody.
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