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{{/_source.additionalInfo}}Anti-Histone H2B (Schizosaccharomyces pombe)
(Cat#: AS21 4558)
Description
- Immunogen: Synthetic peptide corresponding to N-terminal Schizosaccharomyces pombe histone H2B, SAAEKKPASKAPAGKA, UniProt: P04913
- Host: Rabbit
- Clonality: Polyclonal
- Purity: Serum. Contains 0.05% sodium azide.
- Format: Liquid
- Quantity: 50 µl
- Storage: Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
- Tested applications: Chromatin immunoprecipitation (ChIP), Western blot (WB)
- Expected | apparent MW: 1 : 1000 (WB)
- Confirmed reactivity: 13.8 | 17, 24-25 kDa (unmodified and mono-ubiquinated H2B)
- Not reactive in: Species of your interest not listed? Contact us
- In the eukaryotic cells, DNA is packaged repetitively into nucleosomes by means of interactions among two molecules of four classes of histone, H2A, H2B, H3 and H4. Each of the histone proteins has an evolutionarily conserved amino-terminal ‘tail’ that protrudes from the nucleosome. This tail is the target of numerous diverse signaling pathways, resulting in the addition of many post-translational modifications. These modifications include phosphorylation, acetylation, methylation, ADP-ribosylation and mono-ubiquitination. Many important new modifications within the structured core and the carboxy-terminal tail regions of histones are also being identified. It is becoming increasingly clear that these modifications represent crucial regulatory events that govern the accessibility and function of the genome.
- Maruyama et al (2006). Histone H2B mutations in inner region affect ubiquitination, centromere function, silencing and chromosome segregation. EMBO J. 2006 Jun 7;25(11):2420-31. doi: 10.1038/sj.emboj.7601110. Epub 2006 May 11. PMID: 16688222; PMCID: PMC1478186.
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