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{{/_source.additionalInfo}}Human Genome-Wide CRISPRi Dual-sgRNA Library
Human Genome-Wide CRISPRi Dual-sgRNA Library (plasmid), 200ug (Cat# KIDHGW-105K-P)
Description
This off-the-shelf, ready-to-use human genome-wide sgRNA library is designed to inactivate or inhibit gene expression. The CRISPRi sgRNA Library targets nearly 19,000 human protein-coding genes, with 5 sgRNAs per gene. The library uses thesgRNAs in dual combinations across 5 constructs (for example, sgRNA 1 & 2, sgRNA 1 & 3, sgRNA 2 & 3, etc.). Unlike a CRISPR knockout, the induction is reversible since it does not alter the underlying DNA structure. This library provides a tool for identifying candidate therapeutic targets involved in the regulation of growth, differentiation, disease pathogenesis, and other biological responses. Available formats include 200 ug plasmid and pre-packaged viral libraries at 2 x 10^8 TU and 1 x 10^9 TU
- Designed to work with deactivated spCas9 (dCas9) complexed with the KRAB repressor to inactivate or downregulate gene expression
- Library includes 3700 non-targeting sgRNA controls
- Targets nearly 19,000 human coding regions
- Pooled library of ~105,000 dual-sgRNA constructs each targeting a single gene
- 5 CRISPRi dual-sgRNA constructs target each gene
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Targeted Gene Repression
- Loss of Function Studies
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Functional Genetic Screening
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Identification of Novel Targets for Therapeutics
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Biomarker Analysis
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Cat # |
Product Name |
Size |
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KIDHGW-105K-P |
Human Genome-Wide CRISPRiDual-sgRNA Library (plasmid) |
200 ug |
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KIDHGW-106-V8 |
Human Genome-Wide CRISPRiDual-sgRNA Library (virus) |
2 x 10^8 TU |
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KIDHGW-106-V9 |
Human Genome-Wide CRISPRiDual-sgRNA Library (virus) |
1 x 10^9 TU |
Boca Scientific is your premiere source for high-quality, innovative solutions for Cell Biology, Molecular Biology, Immunology, genetics and other lab products and reagents. We bring leading-edge products from our own-line and around the world to laboratories in the US and Canada. Our goal is to offer excellent solutions to drive research and discoveries backed by superior customer support.
